Synthesis, structure elucidation and antimicrobial activity of triorganotin(IV) derivatives of N-laurylsacosine sodium salt

Abstract

Trimethyl(IV) 1, tributyl(IV) 2 and triphenyltin(IV) 3 derivatives of sodium N-laurylsacosinate L-salt, were
synthesized by refluxing triorganotin(IV) chlorides with N-laurylsacosine sodium salt in dry toluene for 7-8 hours in
good yield. Synthesized compounds were structurally elucidated by CHNS elemental analyzer, FTIR,
1H and 13C
NMR spectroscopy. FTIR results showed that compounds exhibited a Penta coordinated solid state geometry. 13C
NMR spectrum of 1 showed that it was dissociated in solution to adopt a 4-coordinated geometry. Antibacterial
activity of the compound 1-3 was investigated against four different strains of bacteria. The results obtained showed
that compounds exhibit moderate to good antibacterial activities.